Summary: NASCIS III. All primary outcome measures of NASCIS III were negative. Post-hoc analyses proved interesting only when the data were arbitrarily restricted to patients treated within 3 to 8 hours of injury, excluding almost 70% of the original study population, and when
bilateral light touch sensation, bilateral pinprick sensation, bilateral deep pain, bilateral pressure, left-sided and bi- lateral motor scores, and right-sided ASIA motor scores were ignored. Even then, the potential treatment effect was lost at 1 year. Analysis of compliance is specially invalid in this protocol because all groups received active medications. Reexamination of the “interesting” raw data....
evidence suggesting harmful side effects ( of using Methylprednisolone) is more consistent than any suggestion of clinical benefit
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